2-Methyl-4-nitroaniline

Synonym(s):2-Amino-5-nitrotoluene;4-Nitro-o-toluidine

CAS NO.：99-52-5
Empirical Formula: C7H8N2O2
Molecular Weight: 152.15
MDL number: MFCD00007734
EINECS: 202-762-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-06-04 16:00:12

What is 2-Methyl-4-nitroaniline?

Chemical properties

Yellowneedle

The Uses of 2-Methyl-4-nitroaniline

2-Methyl-4-nitroaniline was used in preparing in-plane aligned nanofibers by the electrospinning technique. It was the starting reagent in the synthesis of 3-chloro-5-methylphenyl isocyanate. It was used to deposit polycrystalline thin films on Ag, Cu and Si by conventional and partially ionized beam deposition.

The Uses of 2-Methyl-4-nitroaniline

A red azoic dye.

Production Methods

N-Benzenesulfonyl-o-toluidine is dissolved in chlorobenzene at 40 – 50 ℃, and 62 % nitric acid is added gradually to give 5- nitro-N-benzenesulfonyl-o-toluidine, which is isolated and hydrolyzed in sulfuric acid to give 5-nitro-o-toluidine in 80 % yield.

General Description

Yellow needles or mustard yellow powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2-Methyl-4-nitroaniline is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents.

Fire Hazard

Flash point data for 2-Methyl-4-nitroaniline are not available; however, 2-Methyl-4-nitroaniline is probably combustible.

Purification Methods

Crystallise the nitrotoluidine from EtOH. The acetyl and benzoyl derivatives have m 200o and 174o (EtOH) respectively. [Beilstein 12 IV 1809.]

Properties of 2-Methyl-4-nitroaniline

Melting point:	130-132 °C(lit.)
Boiling point:	294.61°C (rough estimate)
Density	1.1586
vapor pressure	20.4hPa at 133.5℃
refractive index	1.6276 (estimate)
Flash point:	157.2℃
storage temp.	Store below +30°C.
solubility	Dichloromethane, DMSO, Ethyl Acetate, Methanol
Colour Index	37100
pka	0.92±0.10(Predicted)
form	Crystalline Powder or Fine Needles
color	Yellow to khaki or brownish
PH	7 (H2O)(aqueous suspension)
Water Solubility	<0.1 g/100 mL at 22 ºC
BRN	775772
CAS DataBase Reference	99-52-5(CAS DataBase Reference)
NIST Chemistry Reference	5-Nitro-2-aminotoluene(99-52-5)
EPA Substance Registry System	2-Methyl-4-nitroaniline (99-52-5)

Safety information for 2-Methyl-4-nitroaniline

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H373:Specific target organ toxicity, repeated exposure H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P314:Get medical advice/attention if you feel unwell. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.