2-Methoxy-5-nitrophenol
Synonym(s):5-Nitroguaiacol
- CAS NO.：636-93-1
- Empirical Formula: C7H7NO4
- Molecular Weight: 169.13
- MDL number: MFCD00015561
- EINECS: 211-269-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 23:30:41
What is 2-Methoxy-5-nitrophenol?
Chemical properties
Yellow to light brown powder
The Uses of 2-Methoxy-5-nitrophenol
2-Methoxy-5-nitrophenol is used in the synthesis of potent VEGF and tyrosine kinase inhibitors. Also used in the synthesis of GABA analogues and phosphodiesterase inhibitors such as rolipram.
Definition
ChEBI: 2-Methoxy-5-nitrophenol is a member of 3-nitrophenols.
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 28, p. 1287, 1980 DOI: 10.1248/cpb.28.1287
General Description
2-Methoxy-5-nitrophenol is the substitution photoproduct formed on irradiation of 2-chloro-4-nitroanisole at 25°C in aqueous NaOH.
Properties of 2-Methoxy-5-nitrophenol
| Melting point: | 103-107 °C (lit.) |
| Boiling point: | 110-112 °C/1 mmHg (lit.) |
| Density | 1.3375 (estimate) |
| refractive index | 1.5830 (rough estimate) |
| Flash point: | 110-112°C/1mm |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 8.31±0.19(Predicted) |
| color | Light Yellow to Light Brown |
| BRN | 2047074 |
| CAS DataBase Reference | 636-93-1(CAS DataBase Reference) |
Safety information for 2-Methoxy-5-nitrophenol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Methoxy-5-nitrophenol
| InChIKey | KXKCTSZYNCDFFG-UHFFFAOYSA-N |
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