2-Iodoaniline
- CAS NO.：615-43-0
- Empirical Formula: C6H6IN
- Molecular Weight: 219.02
- MDL number: MFCD00007680
- EINECS: 210-426-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is 2-Iodoaniline?
Chemical properties
YELLOW TO BROWN CRYSTALLINE NEEDLES
The Uses of 2-Iodoaniline
2-Iodoaniline is used as an intermediate in organic synthesis.
The Uses of 2-Iodoaniline
2-Iodobenzenamine is an synthetic intermediate for the synthesis of complex organic compounds and pharmaceuticals.
Preparation
2-iodoaniline and its derivatives are commonly used for the preparation of indole-based anticancer drugs, which have high market value, and further synthesis can lead to high-end synthetic intermediates with complex structures.
Take a reaction tube, add 50mg of sodium azide, 75mg of 1-(2-iodophenyl)ethanol, 300uL of trifluoroacetic acid, 150uL of methanesulfonic acid and 1.0mL of hexane, and stir for 24 hours at 40℃. After the reaction, 10 mL of sodium hydroxide solution was added to quench the reaction. The organic phase was washed with 5 mL of brine, and the organic phase was combined and separated by column chromatography to obtain 58.4 mg of 2-iodoaniline in 89% yield.
Synthesis of 2-iodoaniline
Purification Methods
Distil 2-iodoaniline with steam and crystallise it from *benzene/pet ether. The N-acetyl derivative has m 110o. [Beilstein 12 IV 1542.]
Properties of 2-Iodoaniline
| Melting point: | 55-58 °C (lit.) |
| Boiling point: | 262.0±23.0 °C(Predicted) |
| Density | 1.8155 (estimate) |
| Flash point: | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Chloroform, DCM, Ethyl Acetate, Toluene |
| pka | 2.6(at 25℃) |
| form | Crystalline Needles |
| color | Yellow to brown |
| Water Solubility | Insoluble in water. |
| Sensitive | Light Sensitive |
| BRN | 2204899 |
| CAS DataBase Reference | 615-43-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzenamine, 2-iodo-(615-43-0) |
| EPA Substance Registry System | o-Iodoaniline (615-43-0) |
Safety information for 2-Iodoaniline
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Iodoaniline
| InChIKey | UBPDKIDWEADHPP-UHFFFAOYSA-N |
2-Iodoaniline manufacturer
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