2-Iodo-4-acetylphenol

The Uses of 2-Iodo-4-acetylphenol

Reactant for:

• Preparation of cyclopentene fused benzofurans and indoles via Pd-catalyzed tandem ring opening-ring closing reaction with diazabicyclic alkenes
• Highly regioselective synthesis of spirocyclic compounds by a palladium-catalyzed intermolecular tandem reaction
• Regioselective synthesis of indene derivatives via Pd/C-catalyzed cyclization reaction in air
• Preparation of carbazoles via cross-coupling with silylaryl triflates followed by palladium-catalyzed cyclization
• Stereoselective preparation of heteropolycyclic compounds via palladium-catalyzed stereoselective heteroannulation of with cyclic alkenes
• Preparation of disubstituted coumarins via palladium-catalyzed carbonylative annulation of internal alkynes
• Preparation of arylalkynes, benzofurans and indoles via Sonogashira coupling and cyclization on alumina

Preparation

Preparation by reaction of iodine and potassium iodide on 4-hydroxyacetophenone in aqueous ammonium hydroxide at r.t. (54–57%).

Synthesis Reference(s)

Journal of Medicinal Chemistry, 23, p. 738, 1980 DOI: 10.1021/jm00181a008