2-Hydroxypyrimidine
- CAS NO.：557-01-7
- Empirical Formula: C4H4N2O
- Molecular Weight: 96.09
- MDL number: MFCD00047358
- EINECS: 209-149-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 00:48:56
What is 2-Hydroxypyrimidine?
The Uses of 2-Hydroxypyrimidine
Pyrimidin-2(5H)-one is a useful research chemical compound used in the preparation . of a palladium-containing metal-organic framework as a reusable catalyst for the Suzuki coupling of p-bromoanisole and phenylboronic acid.
Definition
ChEBI: Pyrimidin-2-ol is the hydroxypyrimidine that is pyrimidine mono-substituted at C-2 by a hydroxy group. It has a role as a Lewis base and an electron donor.
Purification Methods
It crystallises from EtOH or ethyl acetate. Its solubility in H2O at 20o is 1g/2.2mL. [Albert J Chem Soc 4219 1952, Beilstein 24 III/IV 194.]. 2-Hydroxypyrimidine hydrochloride [38353-09-2] M 132.5, has m 203-205.5o(dec)
Properties of 2-Hydroxypyrimidine
| Melting point: | 177-178 °C(Solv: ethyl acetate (141-78-6)) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | pK1:2.24(＋1);pK2:9.17(0) (25°C) |
| CAS DataBase Reference | 557-01-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2(1H)-Pyrimidinone(557-01-7) |
| EPA Substance Registry System | 2(1H)-Pyrimidinone (557-01-7) |
Safety information for 2-Hydroxypyrimidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Hydroxypyrimidine
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