2-Hydroxypyridine
Synonym(s):2(1H)-Pyridone;2-Pyridinol
- CAS NO.：142-08-5
- Empirical Formula: C5H5NO
- Molecular Weight: 95.1
- MDL number: MFCD00006268
- EINECS: 205-520-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:22
What is 2-Hydroxypyridine?
Chemical properties
white to light yellow crystal
The Uses of 2-Hydroxypyridine
2-Hydroxypyridine is a bifunctional catalyst for a wide variety of acylation reactions, catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate. It is used in peptide synthesis.
The Uses of 2-Hydroxypyridine
Catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate.
Definition
ChEBI: 2-Hydroxypyridine is a monohydroxypyridine that is pyridine substituted by a hydroxy group at position 2. It has a role as a plant metabolite.
General Description
2-Hydroxypyridine, an enolic tautomer of 2-pyridone, belongs to the class of volatile organic compounds (VOCs).
Safety Profile
Moderately toxic by intraperitoneal and intravenous routes. A combustible liquid. When heated to decomposition it emits toxic vapors of NOx.
Purification Methods
Distil the pyridone under vacuum to remove coloured impurity, then recrystallise from *benzene, CCl4, EtOH or CHCl3/diethyl ether. It can be sublimed under high vacuum. [DePue et al. J Am Chem Soc 107 2131 1985, Beilstein 21/7 V 106.]
Properties of 2-Hydroxypyridine
| Melting point: | 105-107 °C (lit.) |
| Boiling point: | 280-281 °C (lit.) |
| Density | 1.39 |
| refractive index | 1.5939 (estimate) |
| Flash point: | 210 °C |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 450g/l |
| pka | 0.75(at 20℃) |
| form | Liquid |
| color | Colorless to yellow to brown, darken on storage with no loss of purity |
| Water Solubility | Soluble in water 450 g/L @ 20°C and ethanol, slightly soluble in benzene and ether. |
| BRN | 105786 |
| CAS DataBase Reference | 142-08-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 2(1H)-Pyridinone(142-08-5) |
| EPA Substance Registry System | 2(1H)-Pyridinone (142-08-5) |
Safety information for 2-Hydroxypyridine
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
Computed Descriptors for 2-Hydroxypyridine
2-Hydroxypyridine manufacturer
JSK Chemicals
Clickchem Research LLP
Lorven Biologics Pvt Ltd
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