2-hydroxypropyl-α-cyclodextrin
Synonym(s):α‐HPCD;2‐hydroxypropyl‐α‐CD;2OHpαCD;HPαCD;HP-α-CD
- CAS NO.：128446-33-3
- Molecular Weight: 0
- MDL number: MFCD00197866
- EINECS: 451-510-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-20 14:27:43
What is 2-hydroxypropyl-α-cyclodextrin?
The Uses of 2-hydroxypropyl-α-cyclodextrin
- (2-Hydroxypropyl)-α-cyclodextrin can be used as a chiral selector to resolve tryptophan racemate by capillary electrophoresis.
- It can be used to synthesize biodegradable polyrotaxanes for fabricating blood-contacting devices.
- Co-polymer based on (2-hydroxypropyl)-α-cyclodextrin cross-linked with polyethylenimine can be used as a gene delivery vector.
- It can also be used as stabilizer for antibacterial iodine formulations, as it forms a stable inclusion complex with iodine and improves aqueous solubility.
What are the applications of Application
(2-Hydroxypropyl)-α-cyclodextrin is A modified carbohydrate polymer.
General Description
(2-Hydroxypropyl)-α-cyclodextrin is a hydroxyalkyl derivative of cyclodextrin, which is generally used as a substitute of α-cyclodextrin for potential application in food, cosmetics and pharmaceutical industries. It may be used as a parenteral drug carrier on account of its attractive characteristics such as: a greater extent of solubility in water, high dissolution capacity for weakly soluble analytes, and low toxicity.
Properties of 2-hydroxypropyl-α-cyclodextrin
| Melting point: | 245 °C (dec.)(lit.) |
| Density | 1.39 at 24.6℃ |
| solubility | Soluble in water, methanol, DMF. Insoluble in acetone, chloroform. |
| form | Solid powder |
| color | White to off white |
| optical activity | [α]20/D +125°, c = 1 in H2O |
| EPA Substance Registry System | .alpha.-Cyclodextrin, 2-hydroxypropyl ethers (128446-33-3) |
Safety information for 2-hydroxypropyl-α-cyclodextrin
Computed Descriptors for 2-hydroxypropyl-α-cyclodextrin
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