2-Hydroxyisobutyric acid
Synonym(s):2-Hydroxy-2-methylpropionic acid;2-Methyllactic acid;alpha-Hydroxyisobutyric acid
- CAS NO.：594-61-6
- Empirical Formula: C4H8O3
- Molecular Weight: 104.1
- MDL number: MFCD00004459
- EINECS: 209-848-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-27 08:46:37
What is 2-Hydroxyisobutyric acid?
Chemical properties
white to off-white needle-like crystals or
The Uses of 2-Hydroxyisobutyric acid
2-Hydroxyisobutyric acid is used as background electrolyte for separation and detection of the metal ions by on-line cyclic voltammetry.
The Uses of 2-Hydroxyisobutyric acid
2-Hydroxyisobutyric acid is used as an electrolyte in the separation of the metal ions by on-line cyclic voltammetry. It is also used as a building block for the synthesis of polymers. Its conjugate base, 2-hydroxybutyrate is utilized to catabolize L-threonine as well as synthesize glutathione. Further, it is used as an indicator for the early detection insulin resistance in non-diabetic subjects.
The Uses of 2-Hydroxyisobutyric acid
α-Hydroxyisobutyric acid was used as background electrolyte for separation and detection of the metal ions by on-line cyclic voltammetry.
What are the applications of Application
α-Hydroxyisobutyric acid is a building block for polymer synthesis
Definition
ChEBI: A 2-hydroxy monocarboxylic acid that is isobutyric acid bearing a hydroxy substituent at position 2. It is a metabolite of methyl tertiary-butyl ether.
Synthesis Reference(s)
The Journal of Organic Chemistry, 23, p. 1488, 1958 DOI: 10.1021/jo01104a022
General Description
α-Hydroxyisobutyric acid (2-hydroxyisobutyric acid) is the building block for polymer synthesis. It forms complexes with Eu(III) and has been studied by time resolved fluorescence spectroscopy.
Properties of 2-Hydroxyisobutyric acid
| Melting point: | 76-80 °C(lit.) |
| Boiling point: | 84 °C1.5 mm Hg(lit.) |
| Density | 11412 |
| refractive index | 1.4761 (estimate) |
| Flash point: | 114°C/12mm |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | water: soluble10%, clear to very slightly hazy, colorless |
| form | Solid |
| pka | pK1:3.717 (25°C,μ=0.1) |
| color | White to Off-White |
| Water Solubility | Soluble in water, ether, alcohol, methanol and hot benzene. |
| BRN | 1744739 |
| CAS DataBase Reference | 594-61-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Propanoic acid, 2-hydroxy-2-methyl-(594-61-6) |
| EPA Substance Registry System | Propanoic acid, 2-hydroxy-2-methyl- (594-61-6) |
Safety information for 2-Hydroxyisobutyric acid
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P403+P233:Store in a well-ventilated place. Keep container tightly closed. |
Computed Descriptors for 2-Hydroxyisobutyric acid
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