2-Hydroxybenzimidazole
Synonym(s):2(1H)-Benzimidazolone;2-Hydroxy-benzimidazol
- CAS NO.：615-16-7
- Empirical Formula: C7H6N2O
- Molecular Weight: 134.14
- MDL number: MFCD00127894
- EINECS: 210-412-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is 2-Hydroxybenzimidazole?
Chemical properties
off-white to pale brown crystalline powder
The Uses of 2-Hydroxybenzimidazole
A metabolite of the neuroleptic Droperidol (D679500).
The Uses of 2-Hydroxybenzimidazole
2-Hydroxybenzimidazole (Lansoprazole EP Impurity D(Rabeprazole EP Impurity K)) is a metabolite of the neuroleptic Droperidol (D679500).
Synthesis Reference(s)
The Journal of Organic Chemistry, 33, p. 2543, 1968 DOI: 10.1021/jo01270a093
Synthesis, p. 322, 1991 DOI: 10.1055/s-1991-26457
Tetrahedron Letters, 22, p. 2431, 1981 DOI: 10.1016/S0040-4039(01)92925-9
Safety Profile
Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic vapors of NOx.
Properties of 2-Hydroxybenzimidazole
| Melting point: | >300 °C (lit.) |
| Boiling point: | 247.23°C (rough estimate) |
| Density | 1.2296 (rough estimate) |
| refractive index | 1.5880 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 0.543g/l |
| pka | 11.95±0.10(Predicted) |
| form | Crystalline Powder |
| color | Off-white to pale brown |
| Water Solubility | insoluble |
| BRN | 119866 |
| CAS DataBase Reference | 615-16-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2H-Benzimidazol-2-one, 1,3-dihydro-(615-16-7) |
| EPA Substance Registry System | 2H-Benzimidazol-2-one, 1,3-dihydro- (615-16-7) |
Safety information for 2-Hydroxybenzimidazole
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for 2-Hydroxybenzimidazole
New Products
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![N-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl Lansoprazole Sulfide](https://img.chemicalbook.in/CAS/GIF/1083100-27-9.gif)
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