2-HYDROXY-5-METHYLBENZOPHENONE
- CAS NO.：1470-57-1
- Empirical Formula: C14H12O2
- Molecular Weight: 212.24
- MDL number: MFCD00002379
- EINECS: 216-002-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02
What is 2-HYDROXY-5-METHYLBENZOPHENONE?
Chemical properties
yellow crystalline powder
The Uses of 2-HYDROXY-5-METHYLBENZOPHENONE
2-?Hydroxy-?5-?methylbenzophenone is a general reagent used in the synthesis of anti-bacterial and anti-fungal agents.
Preparation
Preparation by condensation of benzotrichloride with p-cresol,
? in the presence of aluminium chloride in carbon disulfide for 2 h (75%). The 6,12-diphenyl-2,8-dimethyl-6,12-epoxy-6H,12H-dibenzo[b,f] dioxocin, an intermediate compound, was also formed under these conditions (29%). This “dioxocin”, by hydrolysis with concentrated sulfuric acid at r.t., gave the expected ketone (91%);
? in the presence of aqueous sodium hydroxide in a water bath for 4 h (33%) or in 32–40% aqueous sodium hydroxide at 70–80° (67%).
Synthesis Reference(s)
The Journal of Organic Chemistry, 38, p. 1924, 1973 DOI: 10.1021/jo00950a030
Properties of 2-HYDROXY-5-METHYLBENZOPHENONE
| Melting point: | 83-85 °C (lit.) |
| Boiling point: | 312.08°C (rough estimate) |
| Density | 1.1035 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| pka | 8.24±0.43(Predicted) |
| form | powder to crystal |
| color | Light orange to Yellow to Green |
| CAS DataBase Reference | 1470-57-1(CAS DataBase Reference) |
Safety information for 2-HYDROXY-5-METHYLBENZOPHENONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-HYDROXY-5-METHYLBENZOPHENONE
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METHANONE](https://img.chemicalbook.in/CAS/GIF/10425-05-5.gif)
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