2'-hydroxy-5'-methoxypropiophenone

CAS NO.：49710-99-8
Empirical Formula: C10H12O3
Molecular Weight: 180.20048
MDL number: MFCD00598386
EINECS: 2564400
SAFETY DATA SHEET (SDS)
Update Date: 2025-02-12 20:55:48

What is 2'-hydroxy-5'-methoxypropiophenone?

The Uses of 2'-hydroxy-5'-methoxypropiophenone

1-(2-Hydroxy-5-methoxyphenyl)-1-propanone can be used as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.

Preparation

Preparation by Fries rearrangement of p-methoxyphenyl propionate,
with titanium tetrachloride without solvent at 120° for 1 h (74%)
with aluminium chloride in nitrobenzene at 80–100° for 2 h (41%).

Properties of 2'-hydroxy-5'-methoxypropiophenone

Melting point:	47–49°C
storage temp.	Refrigerator
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
color	Pale Yellow Low-Melting

Safety information for 2'-hydroxy-5'-methoxypropiophenone

Computed Descriptors for 2'-hydroxy-5'-methoxypropiophenone

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