2-Hydroxy-5-methoxybenzaldehyde

Synonym(s):2-Hydroxy-5-methoxybenzaldehyde;5-Methoxysalicylaldehyde

CAS NO.：672-13-9
Empirical Formula: C8H8O3
Molecular Weight: 152.15
MDL number: MFCD00003332
EINECS: 211-589-0
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

2-Hydroxy-5-methoxybenzaldehyde Structural

What is 2-Hydroxy-5-methoxybenzaldehyde?

Chemical properties

clear yellow liquid

The Uses of 2-Hydroxy-5-methoxybenzaldehyde

2-Hydroxy-5-methoxybenzaldehyde was used to synthesize radiolabeling precursor desmethyl-PBR06. It was used to study electroantennogram response of the vine weevil (Otiorhynchus sulcatus F.) to a broad range of volatile plant compounds. It was used in the synthesis of tetradentate Schiff base compounds.

The Uses of 2-Hydroxy-5-methoxybenzaldehyde

2-Hydroxy-5-methoxybenzaldehyde is employed to study electroantennogram response of the vine weevil (Otiorhynchus sulcatus F) to a broad range of volatile plant compounds. It plays an important role in the preparation of tetradentate Schiff base compounds. Further, it is used in the preparation 6-methoxy-3-nitro-2H-chromene by using dibutylamine as a reagent.

Definition

ChEBI: 5-methoxysalicylaldehyde is a member of the class of benzaldehydes carrying hydroxy and methoxy substituents at positions 2 and 5 respectively. It is a member of benzaldehydes, a monomethoxybenzene and a member of phenols. It is functionally related to a salicylaldehyde.

General Description

2-Hydroxy-5-methoxybenzaldehyde has acaricidal activity against Tyrophagus putrescentiae.

Properties of 2-Hydroxy-5-methoxybenzaldehyde

Melting point:	4 °C (lit.)
Boiling point:	103 °C/2.5 mmHg (lit.)
Density	1.219 g/mL at 25 °C (lit.)
refractive index	n20/D 1.578(lit.)
Flash point:	>230 °F
storage temp.	Store below +30°C.
form	Liquid
pka	8.66±0.18(Predicted)
color	Clear yellow
Water Solubility	Miscible with chloroform. Slightly miscible with water.
Sensitive	Air Sensitive
BRN	1100532
CAS DataBase Reference	672-13-9(CAS DataBase Reference)
NIST Chemistry Reference	Benzaldehyde, 2-hydroxy-5-methoxy-(672-13-9)

Safety information for 2-Hydroxy-5-methoxybenzaldehyde

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.