2'-Hydroxy-4',5'-dimethoxyacetophenone
- CAS NO.：20628-06-2
- Empirical Formula: C10H12O4
- Molecular Weight: 196.2
- MDL number: MFCD00017241
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:53:56
What is 2'-Hydroxy-4',5'-dimethoxyacetophenone?
The Uses of 2'-Hydroxy-4',5'-dimethoxyacetophenone
1-(2-Hydroxy-4,5-dimethoxyphenyl)ethanone is a useful reagent in Vilsmeier-Haack reaction.
Preparation
Preparation by partial methylation of 2,5-dihydroxy-4-methoxyacetophenone, ? with methyl iodide in the presence of potassium carbonate in refluxing acetone (81%) ; ? with dimethyl sulfate in the presence of potassium carbonate in refluxing acetone (71%), in the presence of sodium methoxide in methanol (byproduct) or in the presence of sodium hydroxide in boiling aqueous ethanol (37%) ; ? with an excess of ethereal diazomethane in methanol (93%).
Properties of 2'-Hydroxy-4',5'-dimethoxyacetophenone
| Melting point: | 113-114°C |
| Boiling point: | 332.3±37.0 °C(Predicted) |
| Density | 1.172±0.06 g/cm3(Predicted) |
| form | powder |
| pka | 10.29±0.23(Predicted) |
| color | White to Light yellow to Light orange |
| CAS DataBase Reference | 20628-06-2(CAS DataBase Reference) |
Safety information for 2'-Hydroxy-4',5'-dimethoxyacetophenone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2'-Hydroxy-4',5'-dimethoxyacetophenone
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