2'-Hydroxy-4'-methylacetophenone
- CAS NO.：6921-64-8
- Empirical Formula: C9H10O2
- Molecular Weight: 150.17
- MDL number: MFCD00100559
- EINECS: 230-040-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-06 19:22:19
What is 2'-Hydroxy-4'-methylacetophenone?
The Uses of 2'-Hydroxy-4'-methylacetophenone
2′-Hydroxy-4′-methylacetophenone is found in Angelica koreana roots and a study was done in which it could be useful for natural acaricides against three mite species.
Preparation
Preparation by treatment of methyl 4-hydroxy-7- methyl-coumarin-3-carboxylate with potassium hydroxide at 200° (87%).
Synthesis Reference(s)
Tetrahedron Letters, 37, p. 4183, 1996 DOI: 10.1016/0040-4039(96)00790-3
General Description
2′-Hydroxy-4′-methylacetophenone, also known as 1-(2-hydroxy-4-methylphenyl)ethanone can be synthesized by the Fries rearrangement of m-tolyl acetate in the presence of zirconium tetrachloride. The results from the toxicity studies on mite species suggest that 2′-hydroxy-4′-methylacetophenone possesses acaricidal property.
Properties of 2'-Hydroxy-4'-methylacetophenone
| Melting point: | 21°C |
| Boiling point: | 245 °C(lit.) |
| Density | 1.08 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| form | clear liquid |
| pka | 10.27±0.10(Predicted) |
| color | Colorless to Light orange to Yellow |
| λmax | 325nm(MeOH)(lit.) |
| CAS DataBase Reference | 6921-64-8(CAS DataBase Reference) |
| EPA Substance Registry System | Ethanone, 1-(2-hydroxy-4-methylphenyl)- (6921-64-8) |
Safety information for 2'-Hydroxy-4'-methylacetophenone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2'-Hydroxy-4'-methylacetophenone
| InChIKey | LYKDOWJROLHYOT-UHFFFAOYSA-N |
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