2-HYDROXY-3-METHYLBUTYRIC ACID
Synonym(s):2-Hydroxyisovaleric acid
- CAS NO.：4026-18-0
- Empirical Formula: C5H10O3
- Molecular Weight: 118.13
- MDL number: MFCD00004242
- EINECS: 223-697-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 01:59:07
What is 2-HYDROXY-3-METHYLBUTYRIC ACID?
Chemical properties
White Solid
The Uses of 2-HYDROXY-3-METHYLBUTYRIC ACID
2-Hydroxy-3-methylbutyric Acid is a α-hydroxylated butyric acid derivative used as a marker in chemical diagnosis of organic aciduria and other inborn errors. 2-Hydroxy-3-methylbutyric Acid is also us ed as a metabolomic biomarkers in preeclampsia.
The Uses of 2-HYDROXY-3-METHYLBUTYRIC ACID
2-Hydroxy-3-methylbutyric acid is employed as internal standard for analysis of ethylene glycol (EG) and γ-hydroxybutyrate (GHB) in whole blood.
Definition
ChEBI: A valine derivative that is valine in which the amino group has been replaced by a hydroxy group.
General Description
Chiral resolution of 2-hydroxy-3-methylbutyric acid without derivatization has been studied by capillary electrophoresis using 2-hydroxypropyl-β-cyclodextrin.
Properties of 2-HYDROXY-3-METHYLBUTYRIC ACID
| Melting point: | 86-87 °C (lit.) |
| Boiling point: | 120-125 °C(Press: 17 Torr) |
| Density | 1.136±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in dimethyl sulfoxide and methanol. |
| form | Solid |
| pka | 3.87±0.16(Predicted) |
| color | White |
| CAS DataBase Reference | 4026-18-0(CAS DataBase Reference) |
Safety information for 2-HYDROXY-3-METHYLBUTYRIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-HYDROXY-3-METHYLBUTYRIC ACID
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