2-Fluorotoluene

Synonym(s):1-Fluoro-2-methylbenzene;2-Fluorotoluene

CAS NO.：95-52-3
Empirical Formula: C7H7F
Molecular Weight: 110.13
MDL number: MFCD00000322
EINECS: 202-428-5
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:37

What is 2-Fluorotoluene?

Chemical properties

clear colorless to slightly yellow liquid

The Uses of 2-Fluorotoluene

It is employed in organic synthesis.

What are the applications of Application

2-Fluorotoluene is a useful fluorinated toluene for proteomics research

General Description

A colorless liquid with an aromatic odor. May sink or float on water.

Air & Water Reactions

Highly flammable. Insoluble in water.

Reactivity Profile

2-Fluorotoluene is of generally low reactivity. Reacts with strong oxidizing agents and strong reducing agents. Also may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides [USCG, 1999].

Health Hazard

Inhalation of vapor may cause respiratory irritation. Prolonged and repeated vapor exposures may produce systemic toxic effects.

Purification Methods

Dry o-fluorotoluene with P2O5 or CaSO4 and fractionally distil it through a silvered vacuum-jacketed glass column with 1/8th-in glass helices. A high reflux ratio is necessary because of the closeness of the boiling points of the o-, m-and p-isomers [Potter & Saylor J Am Chem Soc 37 90 1951]. [Beilstein 5 H 290, 5 III 676, 5 IV 799.]

Properties of 2-Fluorotoluene

Melting point:	-62 °C (lit.)
Boiling point:	113-114 °C (lit.)
Density	1.001 g/mL at 25 °C (lit.)
vapor density	3.8 (vs air)
vapor pressure	21 mm Hg ( 20 °C)
refractive index	n20/D 1.473(lit.)
Flash point:	55 °F
storage temp.	Store below +30°C.
form	Liquid
Specific Gravity	1.001
color	Clear colorless to slightly yellow
explosive limit	1.3%(V)
Water Solubility	immiscible
Merck	14,4180
BRN	1853362
Dielectric constant	4.2199999999999998
CAS DataBase Reference	95-52-3(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1-fluoro-2-methyl-(95-52-3)
EPA Substance Registry System	o-Fluorotoluene (95-52-3)

Safety information for 2-Fluorotoluene

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H225:Flammable liquids H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge.