2'-Fluoroacetophenone
- CAS NO.：445-27-2
- Empirical Formula: C8H7FO
- Molecular Weight: 138.14
- MDL number: MFCD00000320
- EINECS: 207-156-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:59:12
What is 2'-Fluoroacetophenone?
Chemical properties
clear colorless to light yellow or light green
The Uses of 2'-Fluoroacetophenone
2'-Fluoroacetophenone is used as starting reagent in the synthesis of ascididemin. It is used to produce 1-(2-piperidin-1-yl-phenyl)-ethanone by reaction with piperidine.
Synthesis Reference(s)
Tetrahedron Letters, 31, p. 6179, 1990 DOI: 10.1016/S0040-4039(00)97018-7
General Description
The enantioselective reduction of 2′-fluoroacetophenone has been investigated.
Properties of 2'-Fluoroacetophenone
| Melting point: | 26-27C |
| Boiling point: | 187-189 °C(lit.) |
| Density | 1.137 g/mL at 20 °C(lit.) |
| refractive index | n |
| Flash point: | 143 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in Acetone, Chloroform, Dichloromethane, Ethanol, Ethyl Acetate and Methanol. |
| form | Liquid |
| color | Clear colorless to yellow |
| Specific Gravity | 1.121 |
| BRN | 2041344 |
| CAS DataBase Reference | 445-27-2(CAS DataBase Reference) |
| NIST Chemistry Reference | o-Fluoroacetophenone(445-27-2) |
Safety information for 2'-Fluoroacetophenone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 2'-Fluoroacetophenone
| InChIKey | QMATYTFXDIWACW-UHFFFAOYSA-N |
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