2-Fluoro-5-nitrobenzoic acid
- CAS NO.：7304-32-7
- Empirical Formula: C7H4FNO4
- Molecular Weight: 185.11
- MDL number: MFCD00134238
- EINECS: 627-772-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:59:05
What is 2-Fluoro-5-nitrobenzoic acid ?
Chemical properties
white to light yellow crystal powder
The Uses of 2-Fluoro-5-nitrobenzoic acid
2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of:
- dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (SNAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support
- synthesis of substituted dibenzazocines on solid support, via SNAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenols
- in the synthesis of oxazepines
The Uses of 2-Fluoro-5-nitrobenzoic acid
2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (SNAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support, synthesis of substituted dibenzazocines on solid support, via SNAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenols, in the synthesis of oxazepines.
General Description
2-Fluoro-5-nitrobenzoic acid is reported to react with an aldehyde, isonitrile and a primary amine tethered to a Boc-protected internal amino or hydroxyl nucleophile, to afford the Ugi product.
Properties of 2-Fluoro-5-nitrobenzoic acid
| Melting point: | 142-144 °C (lit.) |
| Boiling point: | 337.7±27.0 °C(Predicted) |
| Density | 1.568±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in chloroform, ethanol. |
| form | Crystalline Powder |
| pka | 2.54±0.10(Predicted) |
| color | White to pale yellow |
| BRN | 1912835 |
| CAS DataBase Reference | 7304-32-7(CAS DataBase Reference) |
Safety information for 2-Fluoro-5-nitrobenzoic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Fluoro-5-nitrobenzoic acid
2-Fluoro-5-nitrobenzoic acid manufacturer
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product: 2-Fluoro-5-nitrobenzoicacid 7304-32-7 98%
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