5-Bromo-2-fluoropyridine

CAS NO.：766-11-0
Empirical Formula: C5H3BrFN
Molecular Weight: 175.99
MDL number: MFCD01863742
EINECS: 629-380-1
SAFETY DATA SHEET (SDS)
Update Date: 2025-08-16 20:45:37

What is 5-Bromo-2-fluoropyridine?

Description

5-Bromo-2-fluoropyridine is a halogenated pyridine that has been used as a molecular scaffold for many Active Pharmaceutical Ingredients (APIs) such as Neuropeptide Y Receptor Y5 Inhibitors, SARS-CoV-2 Major Protease Inhibitors, and Indoleamine-2,3-Dioxygenase-1 Inhibitors in cancer immunotherapy. 5-Bromo-2-fluoropyridine is also an ideal building block for semiconductors, due to its aromaticity and electron deficiency. A host material of 5-(5-(2,4,6-triiso-propylphenyl)pyridin-2-yl)-5H-benzo[d]benzo-[4,5]imidazo[1,2-a]imidazole is synthesized from 5-bromo-2-fluoropyridine for OLED applications.

Chemical properties

5-Bromo-2-fluoropyridine is a colourless or yellowish liquid compound with a density of 1.71 g/cm3 at 25° C; boiling point of 162-164° C (lit.) at 750 mmHg; stored at room temperature.

The Uses of 5-Bromo-2-fluoropyridine

2-Fluoro-5-bromopyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. Also used in the synthesis of benzofurano[3,2-d]pyrimidin-2-one derived inhbitors.

Properties of 5-Bromo-2-fluoropyridine

Boiling point:	162-164 °C750 mm Hg(lit.)
Density	1.71 g/mL at 25 °C(lit.)
refractive index	n20/D 1.5325(lit.)
Flash point:	165 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Liquid
pka	-2.79±0.10(Predicted)
Specific Gravity	1.710
color	Clear colorless yellow
BRN	1363171
CAS DataBase Reference	766-11-0(CAS DataBase Reference)

Safety information for 5-Bromo-2-fluoropyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.