2-Ethylhexyl-2-cyano-3-(4-methoxyphenyl)-3-phenylprop-2-enoate

Absorption

Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin . At this time, however, studies demonstrate that the components of most commonly used sunscreens are likely absorbed into the skin at least to some extent - although penetration to deeper tissues and the cutaneous circulation remains limited . Despite the extensive use of sunscreen products around the world, there have been few reports of adverse effects related to their use .

Toxicity

Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal. Additionally, no ocular irritation, phototoxicity, dermal irritation, or allergic contact sensitization has been reported to any significant degree .

Background

Ethylhexyl methoxycrylene is a photostabilizer that preserves the effectiveness of UV filters by interacting with both the singlet and triplet states . It returns UV filters to their ground states without absorbing sunlight . It is used as a solvent for crystalline UV filters and is easily emulsified and suitable for use in various lotions, creams, sprays, sticks, and gel formulations . It currently enjoys regional approvals in Canada, the EU, and the US .

Indications

Ethylhexyl methoxycrylene is employed as a photostabilizing agent in various sunscreen products .

Pharmacokinetics

As an active ingredient in topical sunscreen products, ethylhexyl methoxycrylene is applied directly onto human skin where it acts as a critical component for conferring photostability to the product's other constituent ingredients, protecting the product as a whole from deterioration in the sunlight . Additionally, considering the high log Pow value (6.05-6.32) and low water solubility, dermal absorption of ethylhexyl methoxycrylene is expected to be low. This is supported by a dermal absorption of less than 5% observed for an acceptable analogue of the notified chemical . Consequently, little systemic exposure and pharmacokinetics are expected and users can freely wash off and re-apply ethylhexyl methoxycrylene containing compounds as necessary.

Metabolism

Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal.