2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
Synonym(s):SPhos;S Phos;2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl;2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl impregnated tablets;ChemDose, S-Phos tablets
- CAS NO.：657408-07-6
- Empirical Formula: C26H35O2P
- Molecular Weight: 410.53
- MDL number: MFCD05861611
- EINECS: 613-838-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:26:32
What is 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl?
Chemical properties
White solid
The Uses of 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
suzuki reaction
The Uses of 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
S-Phos is a catalyst that is used in the preparation of thiadiazoles as DGAT1 inhibitors with potential in metabolic diseases treatment.
General Description
SPhos [2-Dicyclohexylphosphino-2′, 6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.
Properties of 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
| Melting point: | 164-166°C |
| Boiling point: | 513.3±40.0 °C(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Chloroform |
| appearance | Colorless solid |
| form | crystal |
| color | white |
| Sensitive | Air Sensitive |
Safety information for 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
| Signal word | Warning |
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H351:Carcinogenicity |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
| InChIKey | VNFWTIYUKDMAOP-UHFFFAOYSA-N |
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl manufacturer
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