2-Chloro-4'-hydroxyacetophenone
- CAS NO.：6305-04-0
- Empirical Formula: C8H7ClO2
- Molecular Weight: 170.59
- MDL number: MFCD00229893
- EINECS: 228-613-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:49:18
What is 2-Chloro-4'-hydroxyacetophenone?
The Uses of 2-Chloro-4'-hydroxyacetophenone
2-Chloro-1-(4-hydroxy-phenyl)-ethanone is a reagent that is used in the preparation of hydroxypyrimidine derivatives and their HDAC (histone deacetylases) inhibitory activity.
Preparation
Also obtained by reaction of acetyl chloride with anisole in the presence of aluminium chloride in n-heptane at 35° for 4 h 30 min (20%).
Properties of 2-Chloro-4'-hydroxyacetophenone
| Melting point: | 145-146 °C |
| Boiling point: | 241.44°C (rough estimate) |
| Density | 1.2315 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| pka | 7.72±0.15(Predicted) |
| CAS DataBase Reference | 6305-04-0(CAS DataBase Reference) |
| EPA Substance Registry System | Ethanone, 2-chloro-1-(4-hydroxyphenyl)- (6305-04-0) |
Safety information for 2-Chloro-4'-hydroxyacetophenone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Chloro-4'-hydroxyacetophenone
New Products
5-bromo-4-fluoro-2-nitrobenzaldehyde (R)-(-)-2-Amino-1-propanol Cyclobutanone Fmoc-OSu 1-(2-Chloroethyl)pyrrolidine Hydrochloride 2-Amino-2-(4-methylphenyl)acetic acid β-Bromostyrene Ethyl 3-phenylpropanoate Phenethyl cinnamate Dipropyl disulfide 4 pentyn 1 ol N-Vinylformamide Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
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