2-chloro-3-fluoropyridin-4-aMine
- CAS NO.：1227577-03-8
- Empirical Formula: C5H4ClFN2
- Molecular Weight: 146.55
- MDL number: MFCD16606117
- EINECS: 818-063-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-24 18:11:54
What is 2-chloro-3-fluoropyridin-4-aMine?
Synthesis
TFA (5 mL) was added to a solution of (2- chloro-3-fluoropyridin-4-yl)carbamic acid fert-butyl ester (1.9 g, 7.7 mmol) in DCM (10 mL). The solution was stirred at ambient temperature for 5 hours and concentrated under reduced pressure. The resultant residue was dissolved in DCM and purified by column chromatography on an NH2 cartridge (0-10 per cent MeOH in DCM) to afford 2-chloro-3-fluoropyridin-4-aMine as a beige solid (0.96 g, 94 per cent yield). NMR (400 MHz, CDC13): δ 7.82 (d, J = 5.4 Hz, 1H), 6.60 (t, J= 5.8 Hz, 1H), 4.38 (br s, 2H).
Properties of 2-chloro-3-fluoropyridin-4-aMine
| Boiling point: | 271.9±35.0 °C(Predicted) |
| Density | 1.449±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 2.81±0.42(Predicted) |
| form | powder |
| color | Brown |
Safety information for 2-chloro-3-fluoropyridin-4-aMine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for 2-chloro-3-fluoropyridin-4-aMine
2-chloro-3-fluoropyridin-4-aMine manufacturer
SAKEM LLP
1Y
Phone:+91-9676889998
Whatsapp: +91-9676889998
product: 2-Chloro-3-fluoro-4-aminopyridine 98%
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