2-(BENZYLOXY)-3-METHOXYBENZALDEHYDE
- CAS NO.：2011-06-5
- Empirical Formula: C15H14O3
- Molecular Weight: 242.27
- MDL number: MFCD00202674
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 00:40:26
What is 2-(BENZYLOXY)-3-METHOXYBENZALDEHYDE?
Chemical properties
Off-white to light yellow crystalline powder
General Description
2-Benzyloxy-3-methoxybenzaldehyde (benzyl-o-vanillin) can be prepared from the reaction of o-vanillin with benzyl bromide in acetone (solvent) and K2CO3 (base) in the presence of tetra-n-butylammonium iodide (catalyst). The dihedral angle between the two benzene rings in 2-benzyloxy-3-methoxybenzaldehyde crystal is 23.33 (6)°. Crystal structure suggests that all O atoms are involved in intra and intermolecular C-HO interactions. It has been reported as key reagent for the synthesis of new anticancer drugs. It is an important pharmacophore in drug discovery. It exhibits anti-proliferative activity in HL60 leukemia cancer cells.
Properties of 2-(BENZYLOXY)-3-METHOXYBENZALDEHYDE
| Melting point: | 44-46 °C(lit.) |
| Boiling point: | 190-195 °C(Press: 3 Torr) |
| Density | 1.154±0.06 g/cm3(Predicted) |
| CAS DataBase Reference | 2011-06-5 |
Safety information for 2-(BENZYLOXY)-3-METHOXYBENZALDEHYDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P362:Take off contaminated clothing and wash before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for 2-(BENZYLOXY)-3-METHOXYBENZALDEHYDE
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