2-Benzylamino-2-methyl-1-propanol

CAS NO.：10250-27-8
Empirical Formula: C11H17NO
Molecular Weight: 179.26
MDL number: MFCD04500950
EINECS: 202-303-5
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-05 20:24:49

What is 2-Benzylamino-2-methyl-1-propanol?

Chemical properties

Yellow-Orange Solid

Synthesis Reference(s)

Tetrahedron, 44, p. 6801, 1988 DOI: 10.1016/S0040-4020(01)86206-2

Synthesis

To a solution of 2-amino-2-methylpropan-1-ol (1 g, 11.22 mmol) and benzaldehyde (1.310 g, 12.34 mmol) in DCE (15 mL) at RT was added portionwise sodium triacetoxyborohydride (6.66 g, 31.4 mmol), and the mixture was stirred for 3 h. The mixture was diluted with EtOAc and washed with saturated aqueous NaHCO3. The organic layer was dried over MgSO4, filtered, and concentrated. The crude product 2-Benzylamino-2-methyl-1-propanol (1.247 g, 6.96 mmol, 62 % yield) was used without further purification. LCMS (m/z): 180.0 (M+H+). synthesis of 2-Benzylamino-2-methyl-1-propanol

Properties of 2-Benzylamino-2-methyl-1-propanol

Melting point:	68-70℃
Boiling point:	300.8±17.0 °C(Predicted)
Density	1.006±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	Chloroform, DMSO, Methanol
form	Solid
pka	14.55±0.10(Predicted)
color	Off-White
InChI	InChI=1S/C11H17NO/c1-11(2,9-13)12-8-10-6-4-3-5-7-10/h3-7,12-13H,8-9H2,1-2H3
CAS DataBase Reference	10250-27-8

Safety information for 2-Benzylamino-2-methyl-1-propanol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.