2-Amino-6-fluorobenzonitrile
Synonym(s):6-Fluoroanthranilonitrile
- CAS NO.：77326-36-4
- Empirical Formula: C7H5FN2
- Molecular Weight: 136.13
- MDL number: MFCD00015477
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-12 09:13:37
What is 2-Amino-6-fluorobenzonitrile?
Chemical properties
white to light yellow crystal powder
The Uses of 2-Amino-6-fluorobenzonitrile
2-Amino-6-fluorobenzonitrile, a medicinal chemistry intermediate, has been employed for the preparation of tacrine-related compounds. It may be used for the synthesis of antifolate and antibacterial quinazoline derivatives.
It may be used for the synthesis bis(4-oxoquinazolin-2-yl)pyridine and fluoro-containing quinazolin-4(1H)-ones. It may be employed for the synthesis of the following novel huprines:
- 12-amino-3-chloro-6,7,10,11-tetrahydro-9-isopropyl-7,11-methanocycloocta[b]quinoline hydrochloride
- 9-allyl-12-amino-3-chloro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline hydrochloride
- 12-amino-1-fluoro-6,7,10,11-tetrahydro-9-isopropyl-7,11-methanocycloocta[b]quinoline hydrochloride
- 9-allyl-12-amino-1-fluoro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline hydrochloride
General Description
2-Amino-6-fluorobenzonitrile can be prepared by treatment of 2,6- difluorobenzonitrile with ammonia, which involves displacement of one of the activated fluorine atoms.
Properties of 2-Amino-6-fluorobenzonitrile
| Melting point: | 125-128 °C (lit.) |
| Boiling point: | 275.8±25.0 °C(Predicted) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform |
| form | Solid |
| pka | 0.80±0.10(Predicted) |
| color | Pale Yellow |
| BRN | 3588945 |
| CAS DataBase Reference | 77326-36-4(CAS DataBase Reference) |
Safety information for 2-Amino-6-fluorobenzonitrile
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Amino-6-fluorobenzonitrile
New Products
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