2-Amino-4-chlorophenol

Synonym(s):2-Amino-4-chlorophenol;5-Chloro-2-hydroxyaniline

CAS NO.：95-85-2
Empirical Formula: C6H6ClNO
Molecular Weight: 143.57
MDL number: MFCD00007694
EINECS: 202-458-9
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is 2-Amino-4-chlorophenol?

Chemical properties

2-Amino-4-chlorophenol is a grayish to light brown crystalline solid or powder

The Uses of 2-Amino-4-chlorophenol

2-Amino-4-chlorophenol is a widely used reagent in the synthesis of various drugs, dyes and pesticides. A reagent in the synthesis of aggrecanase-2 inhibitors based on acylthiosemicarbazide zinc-binding, used in the treatment of osteoarthritis.

The Uses of 2-Amino-4-chlorophenol

Intermediate.

General Description

5-Chloro-2-hydroxyaniline is a light brown colored crystalline solid. 5-Chloro-2-hydroxyaniline may be toxic by ingestion. 5-Chloro-2-hydroxyaniline is insoluble in water. 5-Chloro-2-hydroxyaniline is used to make other chemicals.

Air & Water Reactions

5-Chloro-2-hydroxyaniline may be sensitive to prolonged exposure to air and/or light. Insoluble in water.

Reactivity Profile

5-Chloro-2-hydroxyaniline may react with strong oxidizing agents.

Health Hazard

Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.

Safety Profile

A poison. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx. See also AROMATIC MINES and CHLORIDES.

Potential Exposure

Used as a chemical raw material, especially in dye manufacture

Shipping

UN2673 2-Amino-4-chlorophenol, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, iron, moisture and temperatures .43 C.

Properties of 2-Amino-4-chlorophenol

Melting point:	136-141 °C(lit.)
Boiling point:	185.5°C (rough estimate)
Density	1.2028 (rough estimate)
refractive index	1.5618 (estimate)
storage temp.	2-8°C
solubility	2.3g/l
form	Solid
pka	9.31±0.18(Predicted)
Colour Index	76525
color	Pale Orange to Light Brown
Water Solubility	Insoluble. <0.1 g/100 mL at 20 ºC
BRN	774859
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	95-85-2(CAS DataBase Reference)
NIST Chemistry Reference	5-Chloro-2-hydroxyaniline(95-85-2)
IARC	2B (Vol. 123) 2020
EPA Substance Registry System	2-Amino-4-chlorophenol (95-85-2)

Safety information for 2-Amino-4-chlorophenol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H351:Carcinogenicity
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P308+P313:IF exposed or concerned: Get medical advice/attention.