2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione

Synonym(s):2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione

CAS NO.：192718-06-2
Empirical Formula: C17H8FNO3
Molecular Weight: 293.25
MDL number: MFCD01033540
Update Date: 2026-07-27 17:00:41

2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Structural

What is 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione?

Biological Activity

C527 is a pan-DUB enzyme inhibitor with high activity against USP1/UAF1 complex with IC50 value of 0.88 μM.

in vitro

Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC ₅₀ of 0.88±0.03 μM. C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro . However, the IC ₅₀ of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin. C527 treatments lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents.

Properties of 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione

Boiling point:	488.6±47.0 °C(Predicted)
Density	1.433±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO: soluble0.3mg/mL, clear (warmed)
pka	-4.21±0.20(Predicted)
form	powder
color	faint yellow to dark yellow

Safety information for 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.