2-(4-Fluorophenyl)-thiophene
- CAS NO.：58861-48-6
- Empirical Formula: C10H7FS
- Molecular Weight: 178.23
- MDL number: MFCD06802535
- EINECS: 611-756-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-14 15:27:00
What is 2-(4-Fluorophenyl)-thiophene?
Chemical properties
white solid
The Uses of 2-(4-Fluorophenyl)-thiophene
2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin (C175190) as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus.
Synthesis
4-fluorobenzoic boric acid and 2-bromothiophene, Pd catalyst are added in organic solvent and dissolves, obtain material 3, wherein: 4-fluorine Phenylboric acid molar concentration in organic solvent is 0.5mol/L～2mol/L, and 4-fluorobenzoic boric acid with the mol ratio of 2-bromothiophene is 1:1.0～1:1.5,4-fluorobenzoic boric acid is 1:0.005～1:0.1 with the mol ratio of catalyst；Using material 3 with as material 4 Inorganic base aqueous solution carries out pre-incubation respectively to being 1:1.0～1 according to the mol ratio of 4-fluorobenzoic boric acid Yu alkali after reaction temperature: The mode of 3.0 mixes, and reacts under conditions of 50 ℃～80 ℃, then carries out post processing and obtains 2-(4-fluorophenyl) Thiophene.
Properties of 2-(4-Fluorophenyl)-thiophene
| Melting point: | 51.0 to 55.0 °C |
| Boiling point: | 252.3±15.0 °C(Predicted) |
| Density | 1.200±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | soluble in Methanol |
| form | powder to crystal |
| color | Light orange to Yellow to Green |
| InChI | InChI=1S/C10H7FS/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h1-7H |
| CAS DataBase Reference | 58861-48-6 |
Safety information for 2-(4-Fluorophenyl)-thiophene
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 2-(4-Fluorophenyl)-thiophene
| InChIKey | PURJRGMZIKXDMW-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C(F)C=C2)SC=CC=1 |
2-(4-Fluorophenyl)-thiophene manufacturer
A.J Chemicals
New Delhi
Phone:91-9810153283
Whatsapp: 91-9810153283
product: 2-(4-Fluorophenyl)thiophene
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