2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid
- CAS NO.：1256584-73-2
- Empirical Formula: C12H15IO2
- Molecular Weight: 318.15
- MDL number: MFCD22571222
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-12 09:13:37
What is 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid?
The Uses of 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid
2-?(4-?Ethyl-?3-?iodophenyl)?-?2-?methylpropanoic Acid is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.
Synthesis
2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid is prepared by reacting 4-Ethyl-α,α-dimethylbenzeneacetic acid with N-Iodosuccinimide in Acetic acid for 2h.
Properties of 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid
| Boiling point: | 369.6±27.0 °C(Predicted) |
| Density | 1.547±0.06 g/cm3(Predicted) |
| pka | 4.32±0.11(Predicted) |
| InChI | InChI=1S/C12H15IO2/c1-4-8-5-6-9(7-10(8)13)12(2,3)11(14)15/h5-7H,4H2,1-3H3,(H,14,15) |
Safety information for 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid
| InChIKey | RUVGXZCQYVEAKQ-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C(C1=CC=C(CC)C(I)=C1)(C)C |
2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid manufacturer
Ina pharmaceuticals Pvt Ltd
3Y
Phone:+91-7815933367
Whatsapp: +91-78159 33367
product: 1256584-73-2 99%
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