2-(3,4-Dichlorophenyl)-4-fluoroaniline

CAS NO.：877179-04-9
Empirical Formula: C12H8Cl2FN
Molecular Weight: 256.1
MDL number: MFCD19440920
EINECS: 700-287-9
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 01:05:14

What is 2-(3,4-Dichlorophenyl)-4-fluoroaniline?

Synthesis

8.15 g (97%, 0.042 mol) of 3,4-dichlorophenylboronic acid are initially charged in 50 g of water and 50 g toluene. Subsequently, 18.7 g (0.085 mol) of potassium phosphate and 8.2 g (98%, 0.042 mol) of 2-bromo-4-fluoroaniline are added. After blanketing with nitrogen, 0.014 g (0.00002 mol) of 1,1'-bis(di-test-butyl phosphine) ferrocene palladium dichloride is added, and the mixture is stirred for two hours at 79-81° C. The organic phase is separated and evaporated under reduced pressure, leaving 10.5 g of an oil-crystallized 2-(3,4-Dichlorophenyl)-4-fluoroaniline.

Properties of 2-(3,4-Dichlorophenyl)-4-fluoroaniline

Boiling point:	357℃ at 101.3kPa
Density	1.47 at 20℃
storage temp.	2-8°C
pka	3.22±0.10(Predicted)

Safety information for 2-(3,4-Dichlorophenyl)-4-fluoroaniline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.