2-[2-(2-methoxyethoxy)ethoxy]ethylamine

CAS NO.：74654-07-2
Empirical Formula: C7H17NO3
Molecular Weight: 163.21
MDL number: MFCD17215909
EINECS: 277-952-0
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-11 16:31:51

What is 2-[2-(2-methoxyethoxy)ethoxy]ethylamine?

Description

m-PEG3-amine is a PEG reagent containing an amino group (NH2). The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases solubility in aqueous media.

The Uses of 2-[2-(2-methoxyethoxy)ethoxy]ethylamine

m-PEG3-amine whose chemical name 2-[2-(2-methoxyethoxy)ethoxy]ethylamine,it is a PROTAC bridge, belonging to the PEG class, which can be used to synthesize a series of PROTAC molecules, and can also be used for the synthesis of antibody drug conjugates (ADCs).

Synthesis

2-[2-(2-methoxyethoxy)ethoxy]ethylamine is an organic intermediate, which can be prepared from triethylene glycol monomethyl ether as raw material to prepare 2-(2-(2-methoxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate, and then Reaction with sodium azide,and then Reacts with sodium azide to finally yield 3,6,9-trioxa-1-aminodecane.

Properties of 2-[2-(2-methoxyethoxy)ethoxy]ethylamine

Boiling point:	106℃ (11 Torr)
Density	0.978±0.06 g/cm3(Predicted)
refractive index	1.4395 (589.3 nm 20℃)
storage temp.	2-8°C
solubility	Soluble in Water, DMSO, DCM, DMF
pka	8.74±0.10(Predicted)
color	Colorless to light yellow

Safety information for 2-[2-(2-methoxyethoxy)ethoxy]ethylamine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.