2-(1-Piperazinyl)pyrimidine
Synonym(s):1-(2-Pyrimidyl)piperazine;2-(1-Piperazinyl)pyrimidine;2-(1-Piperazinyl)pyrimidine dihydrochloride;2-Piperazinopyrimidine dihydrochloride
- CAS NO.：20980-22-7
- Empirical Formula: C8H12N4
- Molecular Weight: 164.21
- MDL number: MFCD00040742
- EINECS: 244-135-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 23:59:52
What is 2-(1-Piperazinyl)pyrimidine?
Chemical properties
clear yellow liquid after melting
The Uses of 2-(1-Piperazinyl)pyrimidine
2-(1-Piperazinyl)pyrimidine
The Uses of 2-(1-Piperazinyl)pyrimidine
The major metabolite of Tandospirone.
The Uses of 2-(1-Piperazinyl)pyrimidine
2-(1-Piperazinyl)pyrimidine (Buspirone EP Impurity A) is the major metabolite of Tandospirone (T006430).
Definition
ChEBI: 1-(2-Pyrimidyl)piperazine is a N-arylpiperazine.
Synthesis Reference(s)
The Journal of Organic Chemistry, 18, p. 1484, 1953 DOI: 10.1021/jo50017a004
General Description
1-(2-Pyrimidyl)piperazine is a piperazine-based derivative. It is a metabolite of buspirone.
Properties of 2-(1-Piperazinyl)pyrimidine
| Melting point: | 32-34°C |
| Boiling point: | 277 °C (lit.) |
| Density | 1.158 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid After Melting |
| pka | 8.68±0.10(Predicted) |
| color | Clear yellow |
| Water Solubility | almost transparency |
| Sensitive | Hygroscopic |
| BRN | 151178 |
| CAS DataBase Reference | 20980-22-7(CAS DataBase Reference) |
Safety information for 2-(1-Piperazinyl)pyrimidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-(1-Piperazinyl)pyrimidine
| InChIKey | MRBFGEHILMYPTF-UHFFFAOYSA-N |
2-(1-Piperazinyl)pyrimidine manufacturer
Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)
Maharashtra
product: N-(2-Pyrimidinyl)-piperazine
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