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HomeProduct name list(1S,2S)-(+)-Pseudoephedrine hydrochloride

(1S,2S)-(+)-Pseudoephedrine hydrochloride

Synonym(s):A;Anti-BCEI;Anti-Breast cancer estrogen-inducible protein;Anti-D21S21;Anti-HP1A

  • CAS NO.：345-78-8
  • Empirical Formula: C10H16ClNO
  • Molecular Weight: 201.69
  • MDL number: MFCD00058088
  • EINECS: 206-462-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2026-01-13 11:11:32
(1S,2S)-(+)-Pseudoephedrine hydrochloride Structural

What is (1S,2S)-(+)-Pseudoephedrine hydrochloride?

Chemical properties

white powder

The Uses of (1S,2S)-(+)-Pseudoephedrine hydrochloride

Non-selective adrenergic agonist; decongestant (nasal). Controlled precursor.

Definition

ChEBI: A hydrochloride that is the monohydrochloride salt of pseudoephedrine.

brand name

Efidac (ALZA); Novafed (Sanofi Aventis); Sudafed (GlaxoSmithKline); Sudafed (Warner Lambert).

Contact allergens

This sympathomimetic a-adrenergic agonist is found in plants of the genus Ephedra (Ephedraceae) and is systemically used as a nasal decongestant. It can induce drug skin reactions such as acute generalized exanthematic pustulosis or generalized eczema.

Clinical Use

Nasal decongestant

Drug interactions

Potentially hazardous interactions with other drugs
Adrenergic neurone blockers: antagonise hypotensive effect of adrenergic neurone blockers.
Anaesthetics: increased risk of ventricular arrhythmias with isoflurane.
Antibacterials: risk of hypertensive crisis with linezolid.
Antidepressants: risk of hypertensive crisis with MAOIs and moclobemide.
Dopaminergics: avoid concomitant use with selegiline and rasagiline.

Metabolism

A small amount of pseudoephedrine is hepatically metabolised by N-demethylation.
It is excreted largely unchanged in the urine with small amounts of its hepatic metabolite.

Purification Methods

1S,2S-Pseudoephedrine hydrochloride [345-78-8] M 210.7, m 181-182o, 185-188o, [ + 6 1o (c 1 H2O). Crystallise the salt from EtOH. [Beilstein 13 IV 1878.]

Properties of (1S,2S)-(+)-Pseudoephedrine hydrochloride

Melting point: 185-188 °C(lit.)
alpha  61 º (c=5, H2O,2dm tube)
storage temp.  Refrigerator (+4°C)
solubility  Freely soluble in water and in ethanol (96 per cent), sparingly soluble in methylene chloride.
form  neat
pka 9.22(at 25℃)
Merck  13,8007
BRN  3915112
CAS DataBase Reference 345-78-8(CAS DataBase Reference)
EPA Substance Registry System Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, hydrochloride, (.alpha.S)- (345-78-8)

Safety information for (1S,2S)-(+)-Pseudoephedrine hydrochloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H336:Specific target organ toxicity,single exposure; Narcotic effects
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P271:Use only outdoors or in a well-ventilated area.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Computed Descriptors for (1S,2S)-(+)-Pseudoephedrine hydrochloride

(1S,2S)-(+)-Pseudoephedrine hydrochloride manufacturer

EMBIO LIMITED

Beijing
Phone:91-9004390567
Whatsapp: 91-9004390567
product: d-Pseudoephedrine hydrochloride
Inquiry

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