L-Menthyl acetate
Synonym(s):(1R)-(−)-Menthyl acetate
- CAS NO.：2623-23-6
- Empirical Formula: C12H22O2
- Molecular Weight: 198.3
- MDL number: MFCD00001482
- EINECS: 220-076-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:24:13
What is L-Menthyl acetate?
Chemical properties
(1R)-(-)-Menthyl acetate occurs in peppermint oils. It is a colorless liquid with a fresh, fruity,
peppermint odor.
(?)-Menthyl acetate is prepared by acetylation of (?)-menthol (e.g., with acetic
anhydride). It is used mainly in peppermint flavors and reconstituted peppermint
oils, but also to a small extent in perfumery.
The Uses of L-Menthyl acetate
L-Menthyl Acetate, and its derivatives, is used as a penetration enhancers, to enhance the skin permeation of various drugs with differing lipophilicities, such as 5-aminolevulinic acid (ALA), 5-fluorouracil (5-FU), isosorbide dinitrate (ISDN), lidocaine (LD), etc.
Definition
ChEBI: (-)-Menthyl acetate is a p-menthane monoterpenoid.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
Taste at 25 ppm
Safety Profile
Low toxicity by ingestion and skin contact. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Synthesis
L-Menthyl acetate is produced by direct esterification of racemicMenthol with Acetic acid under azeotropic conditions.
Properties of L-Menthyl acetate
| Melting point: | <25 °C |
| Boiling point: | 229-230 °C(lit.) |
| alpha | -81°(20/D, c=8, C6H6) |
| Density | 0.92 g/mL at 25 °C(lit.) |
| vapor pressure | 45Pa at 20℃ |
| FEMA | 2668 | MENTHYL ACETATE (ISOMER UNSPECIFIED) |
| refractive index | n |
| Flash point: | 171 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | neat |
| form | Liquid |
| color | Colourless |
| Specific Gravity | 0.922 |
| Odor | at 100.00 %. mentholic minty herbal tea fruity woody floral earthy |
| optical activity | [α]20/D 81°, c = 8 in benzene |
| Water Solubility | 23.2mg/L at 20℃ |
| Merck | 14,5839 |
| JECFA Number | 431 |
| BRN | 2208505 |
| CAS DataBase Reference | 2623-23-6(CAS DataBase Reference) |
| EPA Substance Registry System | Cyclohexanol, 5-methyl-2-(1-methylethyl)-, acetate, (1R,2S,5R)- (2623-23-6) |
Safety information for L-Menthyl acetate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H227:Flammable liquids |
| Precautionary Statement Codes |
P403+P235:Store in a well-ventilated place. Keep cool. |
Computed Descriptors for L-Menthyl acetate
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