19-HYDROXY-4-ANDROSTENE-3,17-DIONE
Synonym(s):4-Androsten-19-ol-3,17-dione;4-Androstene-3,17-dione-19-ol
- CAS NO.：510-64-5
- Empirical Formula: C19H26O3
- Molecular Weight: 302.41
- MDL number: MFCD00003616
- EINECS: 208-116-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-04 15:08:30
What is 19-HYDROXY-4-ANDROSTENE-3,17-DIONE?
Chemical properties
Off-White Solid
The Uses of 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
A novel substituted estrogen as aromatase inhibitor
The Uses of 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
19-Hydroxyandrostendione is a novel substituted estrogen as aromatase inhibitor. It induces neuroendocrine trans-differentiation of prostate cancer cells via an ectopic olactory receptor.
Definition
ChEBI: 19-hydroxyandrost-4-ene-3,17-dione is a 19-hydroxy steroid, a 3-oxo steroid, a 17-oxo steroid and an androstanoid. It has a role as a mouse metabolite.
Purification Methods
Recrystallise 19-hydroxy-4-androsten-3,17-dione from Me2CO/hexane or Et2O/hexane. It has UV with max at 242nm in EtOH or MeOH. The 19-acetoxy derivative has [] 26D +185o (CHCl3) and max 237.5nm in EtOH. [Ehrenstein & Dünnenberger J Org Chem 21 774 1956, Beilstein 8 IV2162.]
Properties of 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
| Melting point: | 168-169 °C(lit.) |
| Boiling point: | 485.4±45.0 °C(Predicted) |
| Density | 1.19±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 14.90±0.10(Predicted) |
| color | Off-White to Pale Yellow |
| optical activity | [α]/D +190±5°, c = 1 in chloroform |
| BRN | 2567249 |
| CAS DataBase Reference | 510-64-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 19-Hydroxyandrost-4-ene-3,17-dione(510-64-5) |
Safety information for 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
| Signal word | Warning |
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H361:Reproductive toxicity |
| Precautionary Statement Codes |
P281:Use personal protective equipment as required. |
Computed Descriptors for 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
New Products
Cyclopropane-1,1-dicarboxylic acid Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity tert-Butyl (2S)-[1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl]carbamate 4-amino-2-fluoro-N- methylbenzamide 5-Chloro-3- Methyl -1,3-2-benzoxazol-2(3H)-one N-(2-chloropyrimidin-4-yl)-N,2,3- trimethyl-2H- indazol 6-amine N-Boc-1,4-butanediamine 4-Bromo-2-fluoro-N-methylbenzamide valeronitrile 3-chlorobenzyl cyanide 3,4 Dimethoxy Benzylcyanide 3,4 Diethoxy Benzylcyanide 2-Chloro Benzylcyanide 3-Hydroxypropionitrile 5-azidovalericacid 6,6'-bis(difluoromethoxy)-2,2'-bis((3,4-dimethoxypyridin-2-yl)methylsulfinyl)-1H,1'H-5,5'-bibenzo[d]imidazole (1-((2'-(2-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (1-((2'-(1-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (4-Methoxyphenyl) hydrazine HydrochlorideRelated products of tetrahydrofuran
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