1,8-DICHLOROANTHRAQUINONE

The Uses of 1,8-DICHLOROANTHRAQUINONE

1,8-Dichloroanthraquinone is a reagent in the preparation of anthraquinones, which has antitumor activities. It is used as primary and secondary intermediate.

Safety Profile

An eye irritant. When heated to decomposition it emits toxic fumes of Cl-.

Synthesis

1,8-Dichloroanthraquinone is prepared by the reaction of 1-chloroanthracene-9,10-dione and 2-chloroanthracene-9,10-dione. The steps are as follows:
80 L of the mother liquors obtained according to Example 1a and 40 L of the mother liquors obtained according to Example 1b are combined in a 250 L enamel kettle and heated to 100℃. 12 L of a 10% strength aqueous sodium chlorate solution are fed in at a uniform rate at this temperature in the course of 4 hours, while stirring at 30 - 40 revolutions per minute with an anchor stitter. The mixture is stirred for a further 2 hours at 100℃. and filtered at 80℃. through a filter press, the material on the filter is washed with hot water until the filtrate gives a neutral reaction and the filter cake is dried. 1,8-dichloroanthraquinone are obtained.