17alpha-Hydroxypregnenolone
Synonym(s):3β,17α-Dihydroxy-5-pregnen-20-one;5-Pregnene-3β,17α-diol-20-one
- CAS NO.：387-79-1
- Empirical Formula: C21H32O3
- Molecular Weight: 332.48
- MDL number: MFCD00021129
- EINECS: 206-862-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:51:45
What is 17alpha-Hydroxypregnenolone?
Description
17α-hydroxy Pregnenolone is a metabolite of pregnenolone and a precursor in the biosynthesis of dehydroepiandrosterone (DHEA; ). It is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and then converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity. Plasma levels of 17α-hydroxy pregnenolone are elevated in patients with type II 3β-hydroxysteroid dehydrogenase deficiency, a form of congenital adrenal hyperplasia.
The Uses of 17alpha-Hydroxypregnenolone
17α-hydroxypregnenolone has been used as a substrate for the enzyme 3β‐hydroxysteroid dehydrogenase (3β‐HSD) expressed in COS1 cells.
What are the applications of Application
17α-Hydroxypregnenolone is a C21 steroid and prohormone in the formation of DHEA
General Description
17α-hydroxypregnenolone is a derived from pregnenolone.
Biochem/physiol Actions
17α-hydroxypregnenolone acts as a precursor for cortisol and sex steroids.
Properties of 17alpha-Hydroxypregnenolone
| Melting point: | 273℃ |
| Flash point: | 9℃ |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated) |
| form | Solid |
| Boiling point: | 478.4±45.0 °C(Predicted) |
| Density | 1.15±0.1 g/cm3(Predicted) |
| pka | 13.02±0.70(Predicted) |
| color | White to Off-White |
| CAS DataBase Reference | 387-79-1(CAS DataBase Reference) |
Safety information for 17alpha-Hydroxypregnenolone
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H225:Flammable liquids H370:Specific target organ toxicity, single exposure |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for 17alpha-Hydroxypregnenolone
New Products
2-(2-Chlorophenyl)glycine Propiolic Acid 1-(3-Hydroxy-4-methoxyphenyl)-2-nitroethene (±)-amino(2-fluorophenyl)acetic acid trans-3-Benzyloxy-4-methoxy-beta-nitrostyrene 1-Pentadecanol 4-(4-Αminophenyl)-3-Morpholinone 3-Morpholino-1-(4-(2-oxopiperidin-1-yl) phenyl)-5,6-dihyropyridin-2-(1H)-one 1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one N-cyanoacetylurethane 1H-IndazoleRelated products of tetrahydrofuran
You may like
-
17α-Hydroxypregnenolone CAS 387-79-1View Details
387-79-1 -
17α-Hydroxypregnenolone solution CAS 387-79-1View Details
387-79-1 -
471-25-0 Propiolic Acid 98+View Details
471-25-0 -
84145-28-8 98+View Details
84145-28-8 -
trans-3-Benzyloxy-4-methoxy-beta-nitrostyrene 98+View Details
63909-29-5 -
2-(2-Chlorophenyl)glycine 88744-36-9 98+View Details
88744-36-9 -
40216-83-9 trans-4-Hydroxy-L-proline methyl ester hydrochloride 98+View Details
40216-83-9 -
1-(3-Hydroxy-4-methoxyphenyl)-2-nitroethene 98+View Details
39816-35-8
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.