1,3-dipropyl-8-(3-noradamantyl)xanthine
Synonym(s):1,3-dipropyl-8-(3-noradamantyl)xanthine;8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione;MK-7418;Rolofylline
- CAS NO.：136199-02-5
- Empirical Formula: C20H28N4O2
- Molecular Weight: 356.46
- MDL number: MFCD00899862
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-11-11 10:47:11
What is 1,3-dipropyl-8-(3-noradamantyl)xanthine?
Description
KW 3902 is an antagonist of the adenosine A1 receptor (Ki = 0.19 nM). It displays 890-fold selectivity for A1 receptors over A2A receptors and has no activity at A3 receptors. KW 3902 less potently inhibits human organic anion transporter 1 (OAT1; Ki = 7.82 μM). KW 3902 exhibits renal protective effects during hypoxemia in rabbits.
The Uses of 1,3-dipropyl-8-(3-noradamantyl)xanthine
KW 3902 is an adenosine A1-receptor antagonist, which has recently been shown to alleviate axonopathy caused by human Tau ΔK280. KW 3902 can be considered for the development of a treatment towards hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases.
Definition
ChEBI: Rolofylline is an oxopurine.
Storage
Store at +4°C
Properties of 1,3-dipropyl-8-(3-noradamantyl)xanthine
| Boiling point: | 578.0±42.0 °C(Predicted) |
| Density | 1.262±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble20mg/mL |
| form | solid |
| pka | 9.23±0.70(Predicted) |
| color | White to off-white |
Safety information for 1,3-dipropyl-8-(3-noradamantyl)xanthine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H413:Hazardous to the aquatic environment, long-term hazard |
Computed Descriptors for 1,3-dipropyl-8-(3-noradamantyl)xanthine
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