1,2-Bis(chloromethyl)benzene
Synonym(s):o-Xylylene dichloride;1,2-Bis(chloromethyl)benzene
- CAS NO.：612-12-4
- Empirical Formula: C8H8Cl2
- Molecular Weight: 175.06
- MDL number: MFCD00000903
- EINECS: 210-291-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:14:18
What is 1,2-Bis(chloromethyl)benzene?
Chemical properties
white to light yellow crystal powde
The Uses of 1,2-Bis(chloromethyl)benzene
1,2-Bis(chloromethyl)benzene is used in solid-phase synthesis of large combinatorial variations of fundamental peptide unit 1 .
The Uses of 1,2-Bis(chloromethyl)benzene
α,α′?Dichloro-o-xylene was used in solid-phase synthesis of large combinatorial variations of fundamental peptide unit.
General Description
α,α′-Dichloro-o-xylene reacts with elemental tellurium and NaI in 2-methoxyethanol to form 1,1-diiodo-3,4-benzo-1-telluracyclopentane.
Safety Profile
Poison by intravenous route. Mutation data reported. See also CHLORINATED HYDROCARBONS, AROMATIC. When heated to decomposition it emits toxic Cl-.
Properties of 1,2-Bis(chloromethyl)benzene
| Melting point: | 51-55 °C (lit.) |
| Boiling point: | 239-241 °C (lit.) |
| Density | 1.3930 |
| refractive index | 1.5544 (estimate) |
| Flash point: | 226 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Methanol |
| form | Crystals or Crystalline Powder |
| color | white to light beige |
| Water Solubility | hydrolysis |
| BRN | 2043675 |
| CAS DataBase Reference | 612-12-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1,2-bis(chloromethyl)-(612-12-4) |
| EPA Substance Registry System | 1,2-Bis(chloromethyl)benzene (612-12-4) |
Safety information for 1,2-Bis(chloromethyl)benzene
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1,2-Bis(chloromethyl)benzene
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