11-Piperazinyldibenzo[b,e][1,4]diazepine

CAS NO.：56296-18-5
Empirical Formula: C17H18N4
Molecular Weight: 278.35
MDL number: MFCD25121806
Update Date: 2025-12-05 14:33:18

What is 11-Piperazinyldibenzo[b,e][1,4]diazepine?

Description

DREADD agonist 21 activates hM3Dq (EC₅₀ = 1.7 nM), a designer receptor exclusively activated by designer drugs (DREADD) derived from the human muscarinic acetylcholine M₃ receptor. It does not agonize the hM3 receptor and displays relatively weaker binding affinities for serotonin 5-HT_2A, 5-HT_2C, α_1A-adrenergic, and histamine H₁ receptors (K_is = 66, 170, 280, and 6 nM, respectively).

The Uses of 11-Piperazinyldibenzo[b,e][1,4]diazepine

DREADD agonist 21 is an agonist of hM3Dq, a designer receptor exclusively activated by designer drugs (DREADD). It preferentially binds hM3Dq?DREADDs over endogenous hM3?receptors.

Storage

Room temperature

Properties of 11-Piperazinyldibenzo[b,e][1,4]diazepine

Boiling point:	470.1±55.0 °C(Predicted)
Density	1.28±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.8(Max Conc. mM) Ethanol:29.61(Max Conc. mg/mL);106.39(Max Conc. mM)
form	A crystalline solid
pka	8.56±0.10(Predicted)
color	Yellow

Safety information for 11-Piperazinyldibenzo[b,e][1,4]diazepine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 11-Piperazinyldibenzo[b,e][1,4]diazepine

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