1,1-Cyclopropanedicarboxylic acid

CAS NO.：598-10-7
Empirical Formula: C5H6O4
Molecular Weight: 130.1
MDL number: MFCD00013727
EINECS: 209-917-2
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is 1,1-Cyclopropanedicarboxylic acid?

Chemical properties

white to almost white crystalline powder

The Uses of 1,1-Cyclopropanedicarboxylic acid

1,1-Cyclopropanedicarboxylic acid is used to prepare spiro-cyclopropyl metallocycles.1

The Uses of 1,1-Cyclopropanedicarboxylic acid

1,1-Cyclopropanedicarboxylic acid, is used as an inhibitor of 1-aminocyclopropane-1-carboxylic acid oxidase, was quantitated in Lycopersicum esculentum by HPLC-electrospray tandem mass spectrometry. Crystal and molecular structure of cyclopropane-1,1-dicarboxylic acid has been reported. Cyclopropane-1,1-dicarboxylic acid was used in the preparation of new heterocyclic derivatives of cyclopropane dicarboxylic acid containing thiadiazole and 1,2,4-triazole moieties. It was also used to prepare spiro-cyclopropyl metallocycles. It can also be used as a building block for the synthesis of a series of cyclopropanecarboxamides, having antifungal activity.

General Description

Cyclopropane-1,1-dicarboxylic acid is a dicarboxylic acid. Cyclopropane-1,1-dicarboxylic acid, an inhibitor of 1-aminocyclopropane-1-carboxylic acid oxidase, was quantitated in Lycopersicum esculentum by HPLC-electrospray tandem mass spectrometry. Crystal and molecular structure of cyclopropane-1,1-dicarboxylic acid has been reported.

Purification Methods

Recrystallise the di-acid from CHCl3, EtOAc or *C6H6/Et2O/pet ether. It forms a monohydrate. [Nicolet & Satler J Am Chem Soc 49 2070 1927, Beilstein 9 II 512, 9 III 3795.]

Properties of 1,1-Cyclopropanedicarboxylic acid

Melting point:	134-136 °C(lit.)
Boiling point:	200.75°C (rough estimate)
Density	1.3985 (rough estimate)
refractive index	1.5800 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	methanol: soluble1g/10 mL, clear, colorless
form	powder to crystal
pka	1.82(at 25℃)
color	White to Almost white
Water Solubility	Soluble
BRN	1864823
InChI	InChI=1S/C5H6O4/c6-3(7)5(1-2-5)4(8)9/h1-2H2,(H,6,7)(H,8,9)
CAS DataBase Reference	598-10-7(CAS DataBase Reference)

Safety information for 1,1-Cyclopropanedicarboxylic acid

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.