1,1-Cyclobutanedicarboxylic acid

CAS NO.：5445-51-2
Empirical Formula: C6H8O4
Molecular Weight: 144.13
MDL number: MFCD00001325
EINECS: 226-651-2
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is 1,1-Cyclobutanedicarboxylic acid?

Chemical properties

white fine crystalline powder

The Uses of 1,1-Cyclobutanedicarboxylic acid

1,1-Cyclobutanedicarboxylic Acid is used in the design, studies and structural model of antitumor dicycloplatin a clinical cancer drug. Hydrolysis mechanism of second-generation anticancer drug carboplatin.

Definition

ChEBI: Cyclobutane-1,1-dicarboxylic acid is a cyclobutanedicarboxylic acid. It is a conjugate acid of a cyclobutane-1,1-dicarboxylate(1-).

What are the applications of Application

1,1-Cyclobutanedicarboxylic acid can be used as:
A reactant to synthesize lithium coordination polymer by treating with lithium carbonate.
A ligand to prepare various lanthanide metal-organic frameworks (LnMOFs) via a solvothermal method. Eu+3 based MOF is applicable as a selective chemical sensor for detecting CH3OH due to its high luminescence quantum yield.
It can also be used as a starting material in the synthesis of carboplatin (cis-diammine(1,1-cyclobutanedicarboxyl-ate)platinum(II)).

Properties of 1,1-Cyclobutanedicarboxylic acid

Melting point:	158 °C(lit.)
Boiling point:	222.71°C (rough estimate)
Density	1.3217 (rough estimate)
refractive index	1.5800 (estimate)
storage temp.	Store below +30°C.
solubility	DMSO (Slightly), Methanol (Slightly)
pka	pK1:3.13 ;pK2:5.88 (25°C)
form	Fine Crystalline Powder
color	White
BRN	2046031
CAS DataBase Reference	5445-51-2(CAS DataBase Reference)
NIST Chemistry Reference	1,1-Cyclobutanedicarboxylic acid(5445-51-2)
EPA Substance Registry System	1,1-Cyclobutanedicarboxylic acid (5445-51-2)

Safety information for 1,1-Cyclobutanedicarboxylic acid

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.