10-Gingerol
Synonym(s):(S)- 5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-tetradecanone;10-Gingerol
- CAS NO.：23513-15-7
- Empirical Formula: C21H34O4
- Molecular Weight: 350.49
- MDL number: MFCD01682694
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is 10-Gingerol?
Description
10-Gingerol is a phenol that has been found in Z. officinale and has diverse biological activities. It scavenges DPPH , superoxide, and hydroxyl radicals in cell-free assays (IC50s = 10.47, 1.68, and 1.35 μM, respectively) and inhibits oxidative burst induced by N-formyl-Met-Leu-Phe (fMLP; ) in isolated human polymorphonuclear (PMN) neutrophils when used at a concentration of 6 μM. 10-Gingerol inhibits NETosis and the production of reactive oxygen species (ROS) induced by LPS or lupus-relevant stimuli, including ribonucleoprotein-containing immune complexes and anti-phospholipid antibodies, in isolated human neutrophils. It is active against M. avium and M. tuberculosis (MICs = 25 and 50 μg/ml, respectively). 10-Gingerol (200 μM) is also cytotoxic to human MDA-MB-231 and MDA-MB-468 and murine 4T1 and EO771 mammary carcinoma cells.
The Uses of 10-Gingerol
(+)-(S)-[10]-Gingerol has been observed to exhibit anti-oxidant behaviour towards lipids and is effective in suppressing obesity and adipose tissue inflammation.
Definition
ChEBI: (10)-Gingerol is a beta-hydroxy ketone, a member of phenols and a monomethoxybenzene.
Biochem/physiol Actions
[10]-Gingerol is a bioactive compound found in ginger (Zingiber officinale) with anti-inflammatory and antioxidant activity.
Properties of 10-Gingerol
| Melting point: | 56-58 °C |
| Boiling point: | 499.7±35.0 °C(Predicted) |
| Density | 1.037±0.06 g/cm3(Predicted) |
| Flash point: | 166℃ |
| storage temp. | 2-8°C |
| solubility | methanol: soluble5mg/mL, clear, colorless |
| form | neat |
| form | Solid |
| pka | 10.02±0.20(Predicted) |
| color | Yellow |
| Water Solubility | practically insoluble in water |
Safety information for 10-Gingerol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 10-Gingerol
| InChIKey | AIULWNKTYPZYAN-SFHVURJKSA-N |
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