1-Phenethyl-4-piperidone

Synonym(s):1-(2-Phenylethyl)-4-piperidone;3-(4-Nitrophenyl)propiolic acid methyl ester;Methyl (4-nitrophenyl)-2-propynoate;Methyl 3-(4-nitrophenyl) propiolate;Methyl 3-(4-nitrophenyl)prop-2-ynoate

CAS NO.：39742-60-4
Empirical Formula: C13H17NO
Molecular Weight: 203.28
MDL number: MFCD00006193
EINECS: 254-613-5
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-12 09:16:02

What is 1-Phenethyl-4-piperidone?

Description

1-phenethyl-4-piperidone is a derivative of 4-piperidinone, being used as an intermediate during the manufacture of chemicals. It is applied for the manufacturing of phenethyl derivative of the propanamide as well as the synthesis of l-Phenethylazacycloheptan-4 -one. It is also used in drugs such as illicitly manufactured nonpharmaceutical fentanyl (NPF) (a potent agonist of opioidreceptors used for anaesthesia and analgesia.

Chemical properties

YELLOW-BROWN CRYSTALLINE POWDER

The Uses of 1-Phenethyl-4-piperidone

1-Phenethyl-4-piperidone was used in the preparation of phenethyl derivative of the propanamide. It was also used to synthesize l-Phenethylazacycloheptan-4-one.

The Uses of 1-Phenethyl-4-piperidone

An intermediate of Fentanyl (F275000) and Fenspiride (F265000).

References

https://en.wikipedia.org/wiki/N-Phenethyl-4-piperidinone
Jones, T. S, et al. "Nonpharmaceutical Fentanyl-Related Deaths — Multiple States, April 2005–March 2007." Morbidity & Mortality Weekly Report 57.29(2008): 793-796.
https://www.alfa.com/en/catalog/B21146/

Properties of 1-Phenethyl-4-piperidone

Melting point:	57-60 °C(lit.)
Boiling point:	341.6°C (rough estimate)
Density	1.0156 (rough estimate)
refractive index	1.5400 (estimate)
storage temp.	Store below +30°C.
solubility	ethanol: soluble, clear to hazy, light yellow to yellow (50 mg/mL)
pka	8.02±0.20(Predicted)
form	A crystalline solid
BRN	130302
CAS DataBase Reference	39742-60-4(CAS DataBase Reference)

Safety information for 1-Phenethyl-4-piperidone

Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth.