1-Phenethyl-4-piperidone
Synonym(s):1-(2-Phenylethyl)-4-piperidone;3-(4-Nitrophenyl)propiolic acid methyl ester;Methyl (4-nitrophenyl)-2-propynoate;Methyl 3-(4-nitrophenyl) propiolate;Methyl 3-(4-nitrophenyl)prop-2-ynoate
- CAS NO.：39742-60-4
- Empirical Formula: C13H17NO
- Molecular Weight: 203.28
- MDL number: MFCD00006193
- EINECS: 254-613-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:58
What is 1-Phenethyl-4-piperidone?
Description
1-phenethyl-4-piperidone is a derivative of 4-piperidinone, being used as an intermediate during the manufacture of chemicals. It is applied for the manufacturing of phenethyl derivative of the propanamide as well as the synthesis of l-Phenethylazacycloheptan-4 -one. It is also used in drugs such as illicitly manufactured nonpharmaceutical fentanyl (NPF) (a potent agonist of opioidreceptors used for anaesthesia and analgesia.
Chemical properties
YELLOW-BROWN CRYSTALLINE POWDER
The Uses of 1-Phenethyl-4-piperidone
1-Phenethyl-4-piperidone was used in the preparation of phenethyl derivative of the propanamide. It was also used to synthesize l-Phenethylazacycloheptan-4-one.
The Uses of 1-Phenethyl-4-piperidone
An intermediate of Fentanyl (F275000) and Fenspiride (F265000).
References
https://en.wikipedia.org/wiki/N-Phenethyl-4-piperidinone
Jones, T. S, et al. "Nonpharmaceutical Fentanyl-Related Deaths — Multiple States, April 2005–March 2007." Morbidity & Mortality Weekly Report 57.29(2008): 793-796.
https://www.alfa.com/en/catalog/B21146/
Properties of 1-Phenethyl-4-piperidone
| Melting point: | 57-60 °C(lit.) |
| Boiling point: | 341.6°C (rough estimate) |
| Density | 1.0156 (rough estimate) |
| refractive index | 1.5400 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | ethanol: soluble, clear to hazy, light yellow to yellow (50 mg/mL) |
| pka | 8.02±0.20(Predicted) |
| form | A crystalline solid |
| BRN | 130302 |
| CAS DataBase Reference | 39742-60-4(CAS DataBase Reference) |
Safety information for 1-Phenethyl-4-piperidone
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. |
Computed Descriptors for 1-Phenethyl-4-piperidone
| InChIKey | YDJXNYNKKXZBMP-UHFFFAOYSA-N |
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