1-Naphthol

Synonym(s):α-Naphthol;1-Hydroxynaphthalene;1-Naphthol;Duloxetine impurity D (PhEur)

CAS NO.：90-15-3
Empirical Formula: C10H8O
Molecular Weight: 144.17
MDL number: MFCD00003930
EINECS: 201-969-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-29 17:03:55

What is 1-Naphthol?

Description

1-Naphthol, or α-naphthol, is a fluorescent organic compound with the formula C10H7OH. It is a white solid. It is an isomer of 2-naphthol differing by the location of the hydroxyl group on the naphthalene ring. The naphthols are naphthalene homologues of phenol, with the hydroxyl group being more reactive than in the phenols. Both isomers are soluble in simple alcohols, ethers, and chloroform. They are precursors to a variety of useful compounds. Naphthols (both 1 and 2 isomers) are used as biomarkers for livestock and humans exposed to polycyclic aromatic hydrocarbons.
α-naphtol, combined with epichlorhydrine and sodium hydroxide to form alpha-naphtyl glycidyl ether, caused sensitization in one of three workers in a chemical plant.

The Uses of 1-Naphthol

1-Naphthol is used as a precursor in the manufacturing of various azo dyes and pharmaceuticals such as nadolol. It is used as biomarkers. It is used in analytical chemistry as Molisch's reagent (1-naphthol dissolved in ethanol) for checking the presence of carbohydrates. It plays an essential role with sodium hypobromite to detect the presence of arginine in proteins, which is called as Sakaguchi test.

What are the applications of Application

1-Naphthol is used in the manufacturing of dyes,

Properties of 1-Naphthol

Melting point:	94-96 °C(lit.)
Boiling point:	278-280 °C(lit.)
Density	1.224
Flash point:	125 °C
storage temp.	Store below +30°C.
solubility	Soluble in benzene, chloroform, ether and ethanol.
form	Crystalline Flakes
color	white to off-white
Odor	Slight phenolic odor
Water Solubility	436.7mg/L(25 ºC)
Sensitive	Air & Light Sensitive

Safety information for 1-Naphthol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H311:Acute toxicity,dermal H315:Skin corrosion/irritation H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H371:Specific target organ toxicity, single exposure H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.