1-Methylindole-2-carboxylic acid
Synonym(s):NSC 68357
- CAS NO.：16136-58-6
- Empirical Formula: C10H9NO2
- Molecular Weight: 175.18
- MDL number: MFCD00005801
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 00:26:40
What is 1-Methylindole-2-carboxylic acid?
Chemical properties
Beige crystalline powder
The Uses of 1-Methylindole-2-carboxylic acid
• ;Reactant for preparation of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors1• ;Reactant for synthesis of fenbufen and ethacrynic acid derivatives as potential antitumor agents via amide coupling reactions2• ;Reactant for diastereoselective synthesis of vinylated heterocycles via ruthenium-catalyzed oxidative vinylation with alkenes3• ;Reactant for synthesis of 2,3-dihalo indoles via hypervalent iodine mediated decarboxylative halogenation4• ;Reactant for preparation of α-ketoamides as cathepsin S inhibitors with potential applications ag
The Uses of 1-Methylindole-2-carboxylic acid
- Reactant for preparation of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors
- Reactant for synthesis of fenbufen and ethacrynic acid derivatives as potential antitumor agents via amide coupling reactions
- Reactant for diastereoselective synthesis of vinylated heterocycles via ruthenium-catalyzed oxidative vinylation with alkenes
- Reactant for synthesis of 2,3-dihalo indoles via hypervalent iodine mediated decarboxylative halogenation
- Reactant for preparation of α-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis
- Reactant for preparation of anthranilic acid mimics as bacterial translation inhibitors
What are the applications of Application
1-Methylindole-2-carboxylic acid is a building block used as a reactant in synthesis
General Description
1-Methylindole-2-carboxylic acid reacts with thionyl chloride to yield sulfinyl chlorides.
Properties of 1-Methylindole-2-carboxylic acid
| Melting point: | 212-213 °C (dec.) (lit.) |
| Boiling point: | 389.0±15.0 °C(Predicted) |
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Crystalline Powder |
| pka | 4.19±0.30(Predicted) |
| color | Beige |
| CAS DataBase Reference | 16136-58-6(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Methylindole-2-carboxylic acid(16136-58-6) |
Safety information for 1-Methylindole-2-carboxylic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-Methylindole-2-carboxylic acid
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