1-METHOXY-1,3-CYCLOHEXADIENE

The Uses of 1-METHOXY-1,3-CYCLOHEXADIENE

1-Methoxy-1,3-cyclohexadiene was used in the following studies:

• Synthesis of tetracyclic polyhydroxyquinones via Diels-Alder reaction.
• Synthesis of tetra-ortho-substituted biaryls via Diels-Alder reaction.
• Synthesis of optically active form of dihydroisocoumarin fragment of the gastroprotective natural product AI-77-B, via regiospecific Diels-Alder reaction with an acetylenic ester derivative.

Synthesis Reference(s)

Tetrahedron Letters, 13, p. 4195, 1972 DOI: 10.1016/S0040-4039(01)94273-X

General Description

1-Methoxy-1,3-cyclohexadiene is a useful Diels-Alder diene employed in Diels-Alder cycloadditions. It undergoes Diels-Alder reaction with alkyne to yield anisole derivative.