1-Fluoro-4-iodobenzene

CAS NO.：352-34-1
Empirical Formula: C6H4FI
Molecular Weight: 222
MDL number: MFCD00001052
EINECS: 206-522-7
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-10 10:27:15

What is 1-Fluoro-4-iodobenzene?

Description

4-[18F] Fluoroiodobenzene is a versatile building block in 18F radiochemistry and is used in various transition metal-mediated C-C and C-N cross-coupling reactions. Cross-coupling reaction of 4-fluoroiodobenzene with potassium pentafluorophenyltrifluoroborate in the presence of different palladium catalysts and silver oxide in toluene has been investigated.

Chemical properties

colorless to light yellow liquid

The Uses of 1-Fluoro-4-iodobenzene

suzuki reaction

The Uses of 1-Fluoro-4-iodobenzene

4-Fluoroiodobenzene was used in the preparation of fluorotriphenylene derivatives. 4-[F] Fluoroiodobenzene is a versatile building block in 18F radiochemistry and is used in various transition metal-mediated C-C and C-N cross-coupling reactions.

General Description

4-[¹⁸F] Fluoroiodobenzene is a versatile building block in ¹⁸F radiochemistry and is used in various transition metal-mediated C-C and C-N cross-coupling reactions. Cross-coupling reaction of 4-fluoroiodobenzene with potassium pentafluorophenyltrifluoroborate in the presence of different palladium catalysts and silver oxide in toluene has been investigated.

Properties of 1-Fluoro-4-iodobenzene

Melting point:	-20 °C (lit.)
Boiling point:	182-184 °C (lit.)
Density	1.925 g/mL at 25 °C (lit.)
refractive index	n20/D 1.583(lit.)
Flash point:	155 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Liquid
color	Clear yellow
Specific Gravity	1.925
Water Solubility	Insoluble in water.
Sensitive	Light Sensitive
BRN	1853970
CAS DataBase Reference	352-34-1(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1-fluoro-4-iodo-(352-34-1)
EPA Substance Registry System	p-Fluoroiodobenzene (352-34-1)

Safety information for 1-Fluoro-4-iodobenzene

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.