1-Fluoro-4-iodobenzene
- CAS NO.：352-34-1
- Empirical Formula: C6H4FI
- Molecular Weight: 222
- MDL number: MFCD00001052
- EINECS: 206-522-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:21:34
What is 1-Fluoro-4-iodobenzene?
Description
4-[18F] Fluoroiodobenzene is a versatile building block in 18F radiochemistry and is used in various transition metal-mediated C-C and C-N cross-coupling reactions. Cross-coupling reaction of 4-fluoroiodobenzene with potassium pentafluorophenyltrifluoroborate in the presence of different palladium catalysts and silver oxide in toluene has been investigated.
Chemical properties
colorless to light yellow liquid
The Uses of 1-Fluoro-4-iodobenzene
suzuki reaction
The Uses of 1-Fluoro-4-iodobenzene
4-Fluoroiodobenzene was used in the preparation of fluorotriphenylene derivatives. 4-[F] Fluoroiodobenzene is a versatile building block in 18F radiochemistry and is used in various transition metal-mediated C-C and C-N cross-coupling reactions.
General Description
4-[18F] Fluoroiodobenzene is a versatile building block in 18F radiochemistry and is used in various transition metal-mediated C-C and C-N cross-coupling reactions. Cross-coupling reaction of 4-fluoroiodobenzene with potassium pentafluorophenyltrifluoroborate in the presence of different palladium catalysts and silver oxide in toluene has been investigated.
Properties of 1-Fluoro-4-iodobenzene
| Melting point: | -20 °C (lit.) |
| Boiling point: | 182-184 °C (lit.) |
| Density | 1.925 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 155 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Liquid |
| color | Clear yellow |
| Specific Gravity | 1.925 |
| Water Solubility | Insoluble in water. |
| Sensitive | Light Sensitive |
| BRN | 1853970 |
| CAS DataBase Reference | 352-34-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1-fluoro-4-iodo-(352-34-1) |
| EPA Substance Registry System | p-Fluoroiodobenzene (352-34-1) |
Safety information for 1-Fluoro-4-iodobenzene
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-Fluoro-4-iodobenzene
| InChIKey | KGNQDBQYEBMPFZ-UHFFFAOYSA-N |
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