1-Chloro-3-iodopropane

Synonym(s):Trimethylene chloroiodide

CAS NO.：6940-76-7
Empirical Formula: C3H6ClI
Molecular Weight: 204.44
MDL number: MFCD00001096
EINECS: 230-088-8
SAFETY DATA SHEET (SDS)
Update Date: 2026-09-12 18:56:09

What is 1-Chloro-3-iodopropane?

Chemical properties

CLEAR SLIGHTLY YELLOWISH TO LIGHT PINK LIQUID

The Uses of 1-Chloro-3-iodopropane

1-Chloro-3-iodopropane has been used in the synthesis of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid, an inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase), interesting proton sponge type molecule quino[7,8-h]quinoline.

What are the applications of Application

1-Chloro-3-iodopropane is undergoes asymmetric α-alkylation with N-sulfinyl imidates to yield 2-substituted N-tert-butanesulfinyl-5-chloropentanimidates

General Description

1-Chloro-3-iodopropane undergoes asymmetric α-alkylation with N-sulfinyl imidates to yield 2-substituted N-tert-butanesulfinyl-5-chloropentanimidates. Electroreduction of 1-chloro-3-iodopropane at glassy carbon electrode in dimethylformamide containing tetra-n-butylammonium perchlorate has been investigated by cyclic voltammetry. It also participates in conjugate addition of alkyl iodides to α,β-unsaturated nitriles in water.

Properties of 1-Chloro-3-iodopropane

Boiling point:	170-172 °C (lit.)
Density	1.904 g/mL at 25 °C (lit.)
vapor density	6.8 (vs air)
vapor pressure	2 mm Hg ( 20 °C)
refractive index	n20/D 1.548(lit.)
Flash point:	>230 °F
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Difficult to mix.
form	Liquid
color	Clear light yellow or light pink to orange
Specific Gravity	1.904
Sensitive	Light Sensitive
BRN	1731115
CAS DataBase Reference	6940-76-7(CAS DataBase Reference)
EPA Substance Registry System	Propane, 1-chloro-3-iodo- (6940-76-7)

Safety information for 1-Chloro-3-iodopropane

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.